FET

18F-FET (18F-fluoro-ethyl-tyrosine, Fluoroethyl-L-tyrosine (18F) injection)

18F-fluoro-ethyl-tyrosine (18F-FET) is an artificial amino acid taken up into upregulated tumoral cells but not incorporated into proteins.

18F-FET PET has shown value in the diagnosis of brain tumor recurrence after initial surgery or radiotherapy and for directing biopsy or radiosurgery (Dunet.V. et al. Nucl Med February 1, 2012   vol. 53  no. 2  207-21)

The principal tests for 18F-FET are:

Test

Technic/instrument

Appearance

Visual

Radionuclidic Identity

Gamma-ray spectroscopy with Multichannel analyser

Radionuclidic Identity

Half-life determination with a dose calibrator

pH

pH-meter or pH strips with reading through a reflexion photometer

Chemical purity (Fluoroethyl-L-tyrosine and related substances)     

Gradient HPLC with UV detector

Impurtiy kryptofix  (aminopolyether)

Spot test

Residual solvents and ethanol

Gas chromatography

Bacterial endotoxins (LAL)

Endosafe Portable Test System (PTS)

Radiochemical purity

Radio-HPLC

Radiochemical purity and 18F-fluoride

Radio-TLC

Radiochemical identity

Radio-HPLC

Osmolality

Osmometer

Radionuclidic purity

Gamma-ray spectroscopy  with  Multichannel analyser

Sterility

Compendial method

Radioactivity

Dose calibrator