FEC

18F-FEC (18F-Fluoroethylcholine, Fluorocholine (18F) chloride injection)

18F-labelled choline analogues, such as 2-18F-fluoroethylcholine have been suggested to be useful for the imaging of prostate and brain tumours. 

Indeed, tumour cells with enhanced proliferation rate usually exhibit an improved choline uptake due to the increased membrane phospholipids biosynthesis.  (Asti.M. Nuclear Medicine and Biology, Volume 37, Issue 3, April 2010, Pages 309–315)

The principal tests for 18F-FEC are:

Test

Technic/instrument

Appearance

Visual

Radionuclidic Identity

Gamma-ray spectroscopy with Multichannel analyser

Radionuclidic Identity

Half-life determination with a dose calibrator

pH

pH-meter or pH strips with reading through a reflexion photometer

Impurtiy kryptofix  (aminopolyether)

Spot test

Residual solvents 2-(dimethylamino)ethanol and dibromomethane     

Gas chromatography

Bacterial endotoxins (LAL)

Endosafe Portable Test System (PTS)

Radiochemical purity

Radio-HPLC (isocratic with UV detector)

Radiochemical purity and 18F-fluoride

Radio-TLC

Radiochemical identity

Radio-HPLC

Osmolality

Osmometer

Radionuclidic purity

Gamma-ray spectroscopy with Multichannel analyser

Sterility

Compendial method

Radioactivity

Dose calibrator