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[18F]FEC ([18F]-Fluoroethylcholine, Fluorocholine (18F) chloride injection)
[18F]-labelled choline analogues, such as 2-[18F]-fluoroethylcholine have been suggested to be useful for the imaging of prostate and brain tumours.
Indeed, tumour cells with enhanced proliferation rate usually exhibit an improved choline uptake due to the increased membrane phospholipids biosynthesis. (Asti.M. Nuclear Medicine and Biology, Volume 37, Issue 3, April 2010, Pages 309–315)
The principal tests for [18F]FEC are:
|
Test |
Technique/instrument |
|
Appearance |
Visual |
|
Radionuclidic identity |
Gamma-ray spectroscopy with Multi-Channel Analyser (MUCHA) |
|
Radionuclidic identity |
Half-life determination with a dose calibrator or alternative detector |
|
pH |
pH-meter or pH strips with reading through a reflexion photometer |
|
Impurity kryptofix 222 (aminopolyether) |
Spot test (camera) |
|
Residual solvents including 2- (dimethylamino)ethanol (DMEA) and dibromomethane (DBM) |
Gas Chromatography (GC) |
|
Bacterial endotoxines (LAL) |
Endosafe Portable Test System (NexGen PTS) |
|
Radiochemical purity |
Radio-HPLC (isocratic with UV detetcor) |
|
Radiochemical purity and [18F]-fluoride |
Radio-TLC (miniGITA) |
|
Radiochemical identity |
Radio-HPLC |
|
Osmolality (not compulsory) |
Osmometer |
|
Radionuclidic purity |
Gamma-ray spectroscopy with Multi-Channel Analyser (MUCHA) |
|
Sterility |
Compendial method |
|
Radioactivity (volumic activity) |
Dose calibrator |